Suspected Fulani men in military uniform was said to have attacked the residence of Sunday Igboho in Ibadan, the secessionist spokesman said on Thursday.
Oluyomi Koiki said two people were killed when the men in military uniform breached Mr Igboho’s residence in Soka, just south of Ibadan city centre.
Mr Koiko said that the bodies were taken away by the attackers, but did not immediately disclose the number of those injured.
Footage said to be from the incident contained blood spills in Mr Igboho’s living room. Several vehicles and other valuable assets in the building were also reportedly destroyed.
The identity of the assailants however have not yet been confirmed. A spokesman for the Nigerian Army did not immediately return calls seeking comments about the violence.
The overnight attack came as Mr Igboho was preparing a major rally of separatist agitators scheduled to hold in Lagos on Saturday.
Mr Igboho did not appear to be at home when the attack occurred at about 1:30 a.m. on Thursday. He was on a trip to Germany earlier this month.
Mr Igboho’s campaign has been at odds with Nigerian security forces. His former residence in Ibadan was attacked earlier this year when he held rallies to demand Yoruba’s exit from Nigeria.
Security forces, including operatives of the State Security Service, have clashed with Mr Igboho’s private security team during attempts to arrest him.